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Principal Scientist

Principal Scientist role within ICON:    ICON has a strong reputation in our approaches to clinical development.   We apply scientific and operational excellence across all phases of clinical trial outsourcing services for our clients.   We work with top pharmaceutical organizations on emerging therapeutic areas which include, but are not limited to oncology, diabetes, CNS, cardiovascular and pain.  We are presently in over 40 countries with over 80 offices worldwide and over 13K employees globally.    The Principal Scientist will design, develop, and validate bioanalytical methods for the quantification of peptide and protein novel chemical entities (NCEs) in tissues and biological fluids using LC-MS/MS techniques.  In addition, the Principal Scientist will operate, maintain, and troubleshoot the LC-MS/MS systems.   The Principal Scientist will use the validated methods for routine batch analysis meeting FDA and international regulatory GLP and GCP standards.  The Principal Scientist will be responsible for training others in the operation of instrumentation and the conduct of the validated assays.    Benefits of working at ICON: In addition to partnering with the top pharmaceutical and biotech companies in the world to participate in the development of new medicines at all stages of drug development, we offer a strong benefits package that includes a comprehensive health plan, retirement plans, competitive pay, bonus plans, vacation, and other incentives.     To succeed you will need: We are seeking candidates with a Doctorate in Biochemistry, Analytical Chemistry, Pharmaceutical or Biotechnological Science.   To be successful you will be expected to maintain high quality in a fast paced and collaborative environment, have excellent written and verbal communication skills, including presentation of data, and author technical and regulatory documents.  Hands-on experience with LC-MS/MS instrumentation and quantification of peptides and proteins is required. Experienced in chromatographic techniques for separation of peptides and proteins is expected.  In addition, experience with proteolytic digestion of proteins and peptide mapping is required.   Familiarity with Sciex triple quadrupole instruments and associated software (i.e. Analyst  and MultiQuan) is preferred.   Previous experience in a GLP bioanalytical laboratory is advantageous, but not required. Reference: 052147
Salary Range: NA
Minimum Qualification
Not Specified years

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